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l-Naproxen
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
l-Naproxen图片
CAS NO:23979-41-1
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议

产品介绍
l-Naproxen ((R)-Naproxen) 是 (S)-Naproxen 的对映体异构体,l-Naproxen 可抑制 Cdc42 和 Rac1 (EC50 分别为 96 μM 和 212 μM),并表现出抗肿瘤活性。
Cas No.23979-41-1
别名(R)-萘普生,(R)-Naproxen
分子式C14H14O3
分子量230.26
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

l-Naproxen ((R)-Naproxen) is an enantiomer of (S)-Naproxen. l-Naproxen can inhibit Cdc42 and Rac1 (EC50=96 μM and 212 μM, respectively), and show anti-tumor activity[1][2][3].

l-Naproxen (30-1000 μM; 2 h) inhibits Rac1 and Cdc42 activity selectively in cells[3].l-Naproxen (0-300 μM; 48 h) inhibits migration of immortalized human ovarian cancer cells[3].l-Naproxen (300 μM; 48 h) shows activity via a COX-independent mechanism[3].

[1]. Sonika Batra, et al. Enantiomeric Resolution of (RS)-Naproxen and Application of (S)- Naproxen in the Direct and Indirect Enantioseparation of Racemic Compounds by Liquid Chromatography: A Review. Curr Med Chem. 2017;24(8):758-780.
[2]. M Iwaki, et al. Stereoselective disposition of naproxen glucuronide in the rat. Drug Metab Dispos. 1995 Oct;23(10):1099-103.
[3]. Tudor I Oprea, et al. Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases. PLoS One. 2015 Nov 11;10(11):e0142182.