| CAS NO: | 82768-33-0 |
| 包装 | 价格(元) |
| 500 μg | 电议 |
| 2.5mg | 电议 |
| Cas No. | 82768-33-0 |
| Canonical SMILES | O=C(CC(C(C(C(NC(C1OC(C2=C(C1)C=CC=C2O)=O)CC(C)C)=O)O)O)N)O |
| 分子式 | C20H28N2O8 |
| 分子量 | 424.4 |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Amicoumacin B is an amicoumacin that has been found inN. jinanensisand has quorum-sensing inhibitory activity.1It is active againstC. violaceum(MIC = 250 µg/ml) and reduces the expression of theC. violaceumoperonsvioA,vioB,vioD, andvioE, but increases the expression ofvioC, indicating quorum sensing inhibitory activity.2Amicoumacin B increases the expression of bone morphogenetic protein 2 (BMP2) in MG-63 cells.1,3 1.Sun, W., Zhang, Y.-Q., Huang, Y., et al.Nocardia jinanensis sp. nov., an amicoumacin B-producing actinomyceteInt. J. Syst. Evol. Microbiol.59(Pt 2)417-420(2009) 2.Shi, W.-P., Zeng, H., Wan, C.-X., et al.Amicoumacins from a desert bacterium: quorum sensing inhibitor against Chromobacterium violaceumNat. Prod. Res.(2020) 3.Zhao-Yong, Y., Zhi-Fei, Z., Xiao-Bo, H., et al.Study on the effect of amicoumacin B on up-regulating bmp-2 transcription and expression in MG63 cellsChin. J. Antibiot.33(4)203-205(2008) |
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