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m-PEG3-succinimidyl carbonate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
m-PEG3-succinimidyl carbonate图片
CAS NO:477775-77-2
包装:1g
市场价:7800元

产品介绍
m-PEG3-succinimidyl carbonate 是一种 PROTAC linker,属于 PEG 类,可用于合成 PROTAC。
Cas No.477775-77-2
分子式C12H19NO8
分子量305.28
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

m-PEG3-succinimidyl carbonate is a PEG-basedPROTAC linkercan be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. Miller MA, et al. Amphiphilic conjugates of human brain natriuretic peptide designed for oral delivery: in vitro activity screening. Bioconjug Chem. 2006 Mar-Apr;17(2):267-74.