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Bis-PEG21-NHS ester
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Bis-PEG21-NHS ester图片
CAS NO:2221948-98-5
包装:1g
市场价:21562元

产品介绍
Bis-PEG21-NHS ester 是一种 PROTAC 连接桥，属于 PEG 类和 Alkyl/ether 类。Bis-PEG21-NHS ester 可用于合成一系列 PROTAC 分子。Bis-PEG21-NHS ester 是一种可降解 (cleavable) 的 ADC 连接桥，用于抗体药物结合物 (ADCs) 的合成。
Cas No.2221948-98-5
分子式C54H96N2O29
分子量1237.34
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Bis-PEG21-NHS ester is a PEG/Alkyl/ether-basedPROTAC linkercan be used in the synthesis of PROTACs. Bis-PEG21-NHS ester is a cleavableADC linkerused in the synthesis of antibody-drug conjugates (ADCs)[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[1]. John L. Magnani, et al. Highly potent multimeric e-selectin antagonists. WO2018068010A1