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m-PEG5-succinimidyl carbonate
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
m-PEG5-succinimidyl carbonate图片
CAS NO:1058691-00-1
包装:1g
市场价:13037元

产品介绍
m-PEG5-succinimidyl carbonate 是一种不可降解 (non-cleavable) 的含 5 个单元 PEG 的 ADC linker，可用于合成抗体偶联药物 (ADC)。m-PEG5-succinimidyl carbonate 是一种 PROTAC linker，属于 PEG/Alkyl/ether 类，可用于合成 PROTAC 分子。
Cas No.1058691-00-1
分子式C16H27NO10
分子量393.39
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

m-PEG5-succinimidyl carbonate is a non-cleavable 5 unit PEGADClinker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG5-succinimidyl carbonate is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.