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Propargyl-PEG10-amine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Propargyl-PEG10-amine图片
CAS NO:2112737-25-2
包装:1g
市场价:6062元

产品介绍
Propargyl-PEG10-amine 是一种 PROTAC linker,属于 PEG 类。Propargyl-PEG10-amine 可用于合成一系列 PROTAC 分子。
Cas No.2112737-25-2
分子式C23H45NO10
分子量495.6
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Propargyl-PEG10-amine is a PEG-basedPROTAC linkercan be used in the synthesis of PROTACs.

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[1]. Guangrong Zheng, et al. Bcl-2 proteins degraders for cancer treatment. WO2019144117A1.