您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Tos-PEG4-CH2COOH
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Tos-PEG4-CH2COOH
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tos-PEG4-CH2COOH图片
CAS NO:2028284-73-1
包装:1g
市场价:8870元

产品介绍
Tos-PEG4-CH2COOH 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。
Cas No.2028284-73-1
分子式C17H26O9S
分子量406.45
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tos-PEG4-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34.