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Aspergillimide
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Aspergillimide图片
CAS NO:195966-93-9
包装与价格：
包装价格(元)
1mg电议
5mg电议

产品介绍
Aspergillimide ((rel)-Aspergillimide) 是一种驱虫代谢物，从用 Aspergillus japonicas JV-23 发酵的豆渣中分离得到。
Cas No.195966-93-9
别名(rel)-Aspergillimide; (rel)-VM55598
Canonical SMILESO=C(C1)N(C)C([C@@]21C(C)(C)[C@]3([H])CC45N(CC[C@@H]4C)C[C@]3(N(C)C5=O)C2)=O
分子式C20H29N3O3
分子量359.5
溶解度DMSO: soluble,Ethanol: soluble,Methanol: soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Aspergillimide is a fungal metabolite originally isolated from A. japonicus.1 It reduces nicotinic acetylcholine receptor (nAChR) peak and slowly-desensitizing amplitudes induced by acetylcholine in silkworm (B. mori) larval neurons (IC50s = 20.2 and 39.6 nM, respectively) but has no effect on chicken α3β4-, α4β2-, and α7-containing nAChRs.2 Dietary administration of aspergillimide A (10 μg/g of diet) induces paralysis in silkworm fourth instar larvae.1 Aspergillimide A (10 and 20 mg/kg) reduces T. colubriformis fecal egg count in gerbils.3

References
1. Hayashi, H., Nishimoto, Y., Akiyama, K., et al. New paralytic alkaloids, asperparalines A, B and C, from Aspergillus japonicus JV-23. Biosci. Biotechnol. Biochem. 64(1), 111-115 (2000).
2. Hirata, K., Kataoka, S., Furutani, S., et al. A fungal metabolite asperparaline a strongly and selectively blocks insect nicotinic acetylcholine receptors: The first report on the mode of action. PLoS One 6(4), e18354 (2011).
3. Banks, R.M., Blanchflower, S.E., Everett, J.R., et al. Novel anthelmintic metabolites from an Aspergillus species; the aspergillimides. J. Antibiot. (Tokyo) 50(10), 840-846 (1997).