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NS13001
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NS13001图片
CAS NO:1063331-94-1
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
NS13001 是一种有效的、选择性的、具有口服活性 SK channels (小电导钙激活钾通道) 正向变构调节剂。NS13001 对 SK2 和 SK3 通道的 EC50 分别为 1.8 μM 和 0.14 μM。NS13001 有望作为治疗脊髓小脑共济失调 2 型 (SCA2) 和可能的其他小脑共济失调的潜在治疗剂。
Cas No.1063331-94-1
别名N-(4-氯苯基)-2-(3,5-二甲基-1H-吡唑-1-基)-9-甲基-9H-嘌呤-6-胺
Canonical SMILESCN1C=NC2=C(NC3=CC=C(Cl)C=C3)N=C(N4N=C(C)C=C4C)N=C12
分子式C17H16ClN7
分子量353.81
溶解度DMSO: 100 mg/mL (282.64 mM); Water:< 0.1 mg/mL (insoluble)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

NS13001 is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels). The EC50s are 1.8 and 0.14 μM for SK2 and SK3, respectively. NS13001 holds promise as a potential therapeutic agent for treatment of spinocerebellar ataxia type 2 (SCA2) and possibly other cerebellar ataxias[1].

[1]. Kasumu AW, et al. Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2. Chem Biol. 2012 Oct 26;19(10):1340-53.