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Tocainide hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tocainide hydrochloride图片
CAS NO:71395-14-7
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Tocainide hydrochloride 是一种 sodium channel 阻滞剂,在产生疼痛的病灶中(神经膜上) 阻断钠通道。Tocainide hydrochloride 是利多卡因 (lignocaine) 的一种伯胺类似物,用于治疗心律不齐。
Cas No.71395-14-7
别名N-(2-氨基丙酰基)-2,6-二甲基苯胺
Canonical SMILESCC(N)C(NC1=C(C)C=CC=C1C)=O.[H]Cl
分子式C11H17ClN2O
分子量228.72
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tocainide hydrochloride is a sodium channel blocker, it blocks the sodium channels in the pain-producing foci in the nerve membranes. Tocainide hydrochloride is a primary amine analog of lidocaine, can be used for the treatment of tinnitus[1][2].

Tocainide (100 mg/kg) effectively suppresses ventricular ectopic activity in unanesthetized dogs with coronary occlusion. Termination of tocainide infusion in both digitalis toxicity and coronary occlusion models results in prompt return of ventricular ectopic activity[1].

[1]. Alpert JS, et al. Chemistry, pharmacology, antiarrhythmic efficacy and adverse effects of tocainide hydrochloride, an orally active structural analog of lidocaine. Pharmacotherapy. 1983 Nov-Dec;3(6):316-23. [2]. De Luca A,et al.Optimal requirements for high affinity and use-dependent block of skeletal muscle sodium channel by N-benzyl analogs of tocainide-like compounds.Mol Pharmacol. 2003 Oct;64(4):932-45.