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Org 24598
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Org 24598图片
CAS NO:372198-97-5
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
Potent and selective inhibitor of the glial glycine transporter GlyT1b; active in vivo
Cas No.372198-97-5
别名N-甲基-N-[(3R)-3-苯基-3-[4-(三氟甲基)苯氧基]丙基]甘氨酸
Canonical SMILESCN(CC(O)=O)CC[C@@H](OC2=CC=C(C(F)(F)F)C=C2)C1=CC=CC=C1
分子式C19H20F3NO3
分子量367.36
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Potent and selective inhibitor of the glial glycine transporter GlyT1b (IC50 = 6.9 nM). Displays negligible activity at GlyT-2, adrenoreceptors, dopamine, 5HT receptors and noradrenaline, dopamine, 5HT and GABA transporters (pIC50 in vivo.

Chue et al (2013) Glycine reuptake inhibition as a new therapeutic approach in schizophrenia: focus on the glycine transporter 1 (GlyT1). Curr.Pharm.Des. 19 1311 PMID:23194655 |Brown et al (2001) Discovery and SAR of org 24598-a selective glycine uptake inhibitor. Bioorg.Med.Chem.Lett. 11 2007 PMID:11454468 |Williams et al (2003) Development of a scintillation proximity assay for analysis of Na+/Cl- -dependent neurotransmitter transporter activity. Anal. Biochem. 321 31 PMID:12963052