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Darifenacin-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Darifenacin-d4图片
CAS NO:1189701-43-6
包装与价格:
包装价格(元)
500µg电议
1mg电议
5mg电议
10mg电议

产品介绍
An internal standard for the quantification of darifenacin
Cas No.1189701-43-6
别名(±)-UK-88525-d4
Canonical SMILESNC(C(C1=CC=CC=C1)(C2=CC=CC=C2)C3CN(C([2H])([2H])C([2H])([2H])C4=CC=C(OCC5)C5=C4)CC3)=O
分子式C28H26D4N2O2
分子量430.6
溶解度Acetonitrile: soluble,DMSO: soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Darifenacin-d4is intended for use as an internal standard for the quantification of darifenacin by GC- or LC-MS. Darifenacin is an antagonist of M3muscarinic acetylcholine receptors (mAChRs; Ki= 0.76 nM).1It is selective for M3over M1, M2, M4, and M5mAChRs (Kis = 7.08, 44.67, 45.71, and 9.33 nM, respectively). Darifenacin selectively inhibits contractions in isolated guinea pig ileum, bladder, and trachea (pA2s = 9.44, 8.66, and 8.7, respectively), tissues that endogenously express high levels of M3mAChRs, over isolated rabbit vas deferens and isolated guinea pig atria (pA2s = 7.9 and 7.48, respectively), which endogenously express M1and M2mAChRs, respectively. It inhibits micturition pressure (ED50= 0.089 mg/kg, i.v.), as well as micturition interval and volume in rats. Formulations containing darifenacin have been used in the treatment of overactive bladder.

1.Wallis, R.M., and Napier, C.M.Muscarinic antagonists in development for disorders of smooth muscle functionLife Sci.64(6-7)395-401(1999)