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PF-06649751
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PF-06649751图片
CAS NO:1643489-24-0
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
PF-06649751 (PF-06649751) 是一种具有口服活性的高选择性多巴胺 D1/D5 受体部分激动剂。
Cas No.1643489-24-0
别名PF-06649751; CVL-751
Canonical SMILESO=C1NC(N(C)C(C2=C(C)C=C(OC3=NC=CC=C3C(F)(F)F)C=C2)=C1C)=O
分子式C19H16F3N3O3
分子量391.3
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:20): 0.05 mg/ml,Ethanol: 2 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

PF-06649751 is a dopamine D1and D5receptor partial agonist.1It increases locomotor activity and reduces a global parkinsonian disability score in a macaque model of Parkinson's disease induced by MPTP when administered at a dose of 0.04 mg/kg.

1.Young, D., Popiolek, M., Trapa, P., et al.D1 agonist improved movement of parkinsonian nonhuman primates with limited dyskinesia side effectsACS Chem. Neurosci.11(4)560-566(2020)