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Methylatropine(nitrate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Methylatropine(nitrate)图片
CAS NO:52-88-0
包装与价格:
包装价格(元)
5mg电议
25mg电议
50mg电议
100mg电议

产品介绍
A muscarinic acetylcholine receptor antagonist
Cas No.52-88-0
别名甲硝阿托品
Canonical SMILESC[N+]1([C@H](CC[C@H]1C2)C[C@@H]2OC(C(C3=CC=CC=C3)CO)=O)C.O=[N]([O-])=O
分子式C18H26NO3•NO3
分子量366.4
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Methylatropine is an antagonist of muscarinic acetylcholine receptors (IC50=<0.1 nM in a radioligand binding assay using isolated porcine brain membranes) and a derivative of atropine .1,2It reduces acetylcholine-induced decreases in blood pressure in rats when administered intravenously with an ED50value of 5.5 µg/kg.2Methylatropine reduces salivation, induces mydriasis, and increases heart rate in dogs.3

1.Schmeller, T., Sporer, F., Sauerwein, M., et al.Binding of tropane alkaloids to nicotinic and muscarinic acetylcholine receptorsPharmazie50(7)493-495(1995) 2.Brezenoff, H.E., Xiao, Y.-F., and Vargas, H.A comparison of the central and peripheral antimuscarinic effects of atropine and methylatropine injected systemically and into the cerebral ventriclesLife Sci.42(8)905-911(1988) 3.Albanus, L.Central and peripheral effects of anticholinergic compoundsActa Pharmacol. Toxicol. (Copenh)28(4)305-326(1970)