您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Tasimelteon-d5
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Tasimelteon-d5
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tasimelteon-d5图片
CAS NO:1962124-51-1
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
An internal standard for the quantification of tasimelteon
Cas No.1962124-51-1
别名BMS-214778-d5; VEC-162-d5
Canonical SMILESO=C(C([2H])([2H])C([2H])([2H])[2H])NC[C@@H]1C[C@@]1([H])C2=C3C(OCC3)=CC=C2
分子式C15H14D5NO2
分子量250.4
溶解度Acetonitrile: soluble,DMF: soluble,DMSO: soluble,Methanol: soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tasimelteon-d5is intended for use as an internal standard for the quantification of tasimelteon by GC- or LC-MS. Tasimelteon is a melatonin (MT) receptor agonist.1It selectively binds MT1and MT2receptors (Kis = 0.304 and 0.069 nM, respectively, in NIH3T3 cells expressing the recombinant human receptors) over a panel of 160 additional receptors and enzymes at 10 µM. Tasimelteon inhibits forskolin-induced cAMP accumulation with EC50values of 0.79 and 1 nM in NIH3T3 cells expressing the MT1or MT2receptor, respectively. Formulations containing tasimelteon have been used in the treatment of non-24-hour sleep-wake disorder.

1.Lavedan, C., Forsberg, M., and Gentile, A.J.Tasimelteon: A selective and unique receptor binding profileNeuropharmacology91142-147(2015)