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Teriflunomide impurity 3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Teriflunomide impurity 3图片
CAS NO:1011244-72-6
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Teriflunomideimpurity3(4-Amino-N-(4-trifluoromethylphenyl)benzamide)是一种选择性COX-1抑制剂,IC50为30µM,对COX-2的活性较低(IC50>100µM)。
Cas No.1011244-72-6
别名4-Amino-N-(4-trifluoromethylphenyl)benzamide
Canonical SMILESO=C(NC1=CC=C(C(F)(F)F)C=C1)C2=CC=C(N)C=C2
分子式C14H11F3N2O
分子量280.25
溶解度DMSO: 250 mg/mL (892.06 mM)
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide) is a selective COX-1 inhibitor with an IC50 of 30 µM. Teriflunomide impurity 3 is less active against COX-2 (IC50>100 µM)[1].

Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide; compound 11q) is an amide-bond-reversed compound bearing trifluoromethyl and amino substituents showed potent COX-1-selective inhibitory activity[1].

[1]. Hiroki Kakuta, et al. Cyclooxygenase-1-selective inhibitors are attractive candidates for analgesics that do not cause gastric damage. design and in vitro/in vivo evaluation of a benzamide-type cyclooxygenase-1 selective inhibitor. J Med Chem. 2008 Apr 24;51(8):2400-11.