| 包装 | 价格(元) |
| 500 µg | 电议 |
| 1mg | 电议 |
| 5mg | 电议 |
| Canonical SMILES | O=C(NCC1CCCN1CC=C)C2=C(O[13C]([2H])([2H])[2H])C=C(NN=N3)C3=C2.Cl |
| 分子式 | C15[13C]H18D3N5O2·HCl |
| 分子量 | 355.9 |
| 溶解度 | DMSO: soluble,Methanol: soluble,Water: soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Alizapride-13C-d3is intended for use as an internal standard for the quantification of alizapride by GC- or LC-MS. Alizapride is a dopamine D2receptor antagonist (Ki= 66-340 nM in radioligand binding assays).1It is selective for dopamine D2over α1-, α2-, and β-adrenergic receptors (IC50s = >10 µM for all). It reduces decreases in gastrointestinal transit induced by dopamine , apomorphine, or bromocriptine in rats when administered at a dose of 5 mg/kg.2Formulations containing alizapride have been used in the treatment of pre- and postoperative nausea. 1.Chivers, J.K., Gommeren, W., Leysen, J.E., et al.Comparison of the in-vitro receptor selectivity of substituted benzamide drugs for brain neurotransmitter receptorsJ. Pharm. Pharmacol.40(6)415-421(1988) 2.Dhasmana, K.M., VillalÓn, C.M., Zhu, Y.N., et al.The role of dopamine (D2), α and β-adrenoceptor receptors in the decrease in gastrointestinal transit induced by dopamine and dopamine-related drugs in the ratPharmacol. Res.27(4)335-347(1993) |
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