| CAS NO: | 17954-98-2 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| Cas No. | 17954-98-2 |
| 别名 | 22(R)-羟基胆固醇,Narthesterol |
| 化学名 | cholest-5-ene-3β,22R-diol |
| Canonical SMILES | CC(C)CC[C@@H](O)[C@@H](C)C1CCC2C3CC=C4C[C@@H](O)CC[C@]4(C)C3CC[C@@]21C |
| 分子式 | C27H46O2 |
| 分子量 | 402.7 |
| 溶解度 | ≤20mg/ml in ethanol;0.1mg/ml in DMSO;2mg/ml in dimethyl formamide |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | EC50: 325 nM 22(R)-hydroxy cholesterol is an endogenous agonist for liver X receptors (LXRs). The liver X receptors, LXRR and LXRα, together with the farnesoid X receptor, FXR, form a subfamily of these orphan receptors. Recently, it has been reported that LXR and FXR are hormone receptors for oxysterols and bile acids, respectively. In vitro: Previous study found that 22(R)-hydroxycholesterol was only found in the adrenals as an intermediate in pregnenolone biosynthesis, not similar with 24(R), 25-epoxycholesterol and 20(S)-hydroxycholesterol. In addition, the hydroxyl groups of 22(R)-hydroxycholesterol as well as its analogs of 23(S)-hydroxycholesterol and 24(S)-hydroxycholesterol would all lie between 2.0-2.5 from Trp443 [1]. In another study, the ABC1 mRNA expression could be induced in an additive fashion by 22(R)-hydroxycholesterol and 9-cis-retinoic acid in cultured macrophages, indicating induction by nuclear hormone receptors of the liver X receptor and retinoid X receptor family. Moreover, the upstream promoter was induced 7-fold by the treatment of 22(R)-hydroxycholesterol when transfected into RAW macrophages [2]. In vivo: So far, there is no animal in vivo data reported. Clinical trial: Up to now, 22(R)-hydroxy cholesterol is still in the preclinical development stage. References: |
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