| CAS NO: | 344327-48-6 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 50mg | 电议 |
| Cas No. | 344327-48-6 |
| 别名 | APD |
| 化学名 | 6-(acetyloxy)-1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-1-phenanthrenecarboxylic acid, anhydride |
| Canonical SMILES | CC(=O)Oc1ccc2CC[C@H]3[C@](C)(CCC[C@]3(C)c2c1)[C@@H](=O)O[C@H](=O)[C@@]1(C)CCC[C@]2(C)c3cc(ccc3CC[C@@H]12)OC(=O)C |
| 分子式 | C38H46O7 |
| 分子量 | 614.8 |
| 溶解度 | ≤1mg/ml in dimethyl formamide |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Target: LXR ED50: 1 nM Acetyl podocarpic acid anhydride (APD) is a kind of potent, semi-synthetic agonist of liver X receptor (LXR), which was derived from the extracts of the mayapple [1]. The liver X receptor is a member of the nuclear receptor family of transcription factors and is closely related to nuclear receptors such as the farnesoid X receptor (FXR), Peroxisome proliferator-activated receptor (PPARs) and retinoid X receptor (RXR). LXRs are key regulators involved in fatty acid, cholesterol, and glucose homeostasis. APD could inhibit the overall absorption of cholesterol by increasing the efflux of cholesterol from enterocytes, with the ED50 value of 1 nM [2]. In Vitro: In a cell-free assay of receptor activation, APD could cause LXR to bind to SRC-1, with a much more potentiality than 22-(R)-hydroxycholesterol. Besides, in THP-1 human primary hepatocytes, and Caco-2 cells, APD could significantly increase the mRNA level of ABCA1, which was regulated by LXR [2]. In Vivo: no data available. Clinical trial: no data available. References: |
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