您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Quinestrol
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Quinestrol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Quinestrol图片
CAS NO:152-43-2
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
250mg电议
500mg电议
1g电议

产品介绍
Quinestrol 是一种合成雌激素,用于激素替代疗法,偶尔用于治疗乳腺癌和前列腺癌
Cas No.152-43-2
别名炔雌醇环戊醚,Estrovis?,Ethynyl Estradiol-3-cyclopentyl ether,W 3566
化学名3-(cyclopentyloxy)-19-norpregna-1,3,5(10)-trien-20-yn-17α-ol
Canonical SMILESC[C@@]12[C@@]([H])(CC[C@@]2(O)C#C)[C@]([C@]3([H])CC1)([H])CCC4=C3C=CC(OC5CCCC5)=C4
分子式C25H32O2
分子量364.5
溶解度≥ 12.15mg/mL in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Quinestrol is a synthetic estrogen that is effective in hormone replacement therapy after the menopause [1][2].

Estrogen has extraordinarily complex biological effects in diverse tissues such as skeletal, urogenital, digestive, cardiovascular, ocular and nervous systems. Apart from estrogens, selective estrogen receptor modulators may be used for prevention of some of the long-term consequences of estrogen deficiency [2].

Quinestrol is 3-cyclopentyl ether of ethynyl estradiol. After gastrointestinal absorption, Quinestrol is stored in adipose tissue, where it is slowly released and metabolized in the liver to its active form, ethinyl estradiol.

In adult male mice, quinestrol reduced sperm counts and increased the number of abnormal spermatozoa. Quinestrol stimulated oxidative stress to induce apoptosis in spermatogenic cells through the mitochondrial and death receptor pathways [3]. In adult male rat, quinestrol significantly increased the number of germ cells expressing caspase-3, Bax, Fas and FasL, and reduced the number of cells expressing Bcl-2 and PCNA. These results suggested that quinestrol induced abnormal spermatogenesis through the mitochondrial- and Fas-L-mediated pathways [4].

References:
[1].  Baumgardner SB, Condrea H, Daane TA, et al. Replacement estrogen therapy for menopausal vasomotor flushes. Comparison of quinestrol and conjugated estrogens. Obstet Gynecol. 1978 Apr;51(4):445-52.
[2].  Skouby, S.O. Criteria for the selection of an optimal estrogen replacement. Gynecological Endocrinology 15, 60-67 (2001).
[3].  Li J, Chen F, Li C,et al. Quinestrol induces spermatogenic apoptosis in vivo via increasing pro-apoptotic proteins in adult male mice. Tissue Cell. 2014 Oct;46(5):318-25.
[4].  Li J, Chen F, Chen Y, et al. Mitochondrial- and Fas-L-mediated pathways involved in quinestrol induced spermatogenic apoptosis in adult rat testes. Toxicol Mech Methods. 2014 Dec;24(9):609-15.