CAS NO: | 152-43-2 |
包装 | 价格(元) |
10mM (in 1mL DMSO) | 电议 |
250mg | 电议 |
500mg | 电议 |
1g | 电议 |
Cas No. | 152-43-2 |
别名 | 炔雌醇环戊醚,Estrovis?,Ethynyl Estradiol-3-cyclopentyl ether,W 3566 |
化学名 | 3-(cyclopentyloxy)-19-norpregna-1,3,5(10)-trien-20-yn-17α-ol |
Canonical SMILES | C[C@@]12[C@@]([H])(CC[C@@]2(O)C#C)[C@]([C@]3([H])CC1)([H])CCC4=C3C=CC(OC5CCCC5)=C4 |
分子式 | C25H32O2 |
分子量 | 364.5 |
溶解度 | ≥ 12.15mg/mL in DMSO |
储存条件 | Store at -20℃ |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Quinestrol is a synthetic estrogen that is effective in hormone replacement therapy after the menopause [1][2]. Estrogen has extraordinarily complex biological effects in diverse tissues such as skeletal, urogenital, digestive, cardiovascular, ocular and nervous systems. Apart from estrogens, selective estrogen receptor modulators may be used for prevention of some of the long-term consequences of estrogen deficiency [2]. Quinestrol is 3-cyclopentyl ether of ethynyl estradiol. After gastrointestinal absorption, Quinestrol is stored in adipose tissue, where it is slowly released and metabolized in the liver to its active form, ethinyl estradiol. In adult male mice, quinestrol reduced sperm counts and increased the number of abnormal spermatozoa. Quinestrol stimulated oxidative stress to induce apoptosis in spermatogenic cells through the mitochondrial and death receptor pathways [3]. In adult male rat, quinestrol significantly increased the number of germ cells expressing caspase-3, Bax, Fas and FasL, and reduced the number of cells expressing Bcl-2 and PCNA. These results suggested that quinestrol induced abnormal spermatogenesis through the mitochondrial- and Fas-L-mediated pathways [4]. References: |