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3,3',5'-Triiodo-L-thyronine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
3,3',5'-Triiodo-L-thyronine图片
CAS NO:5817-39-0
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
3,3',5'-三碘-L-甲状腺素是一种甲状腺激素,由激素原甲状腺素脱碘产生。
Cas No.5817-39-0
别名碘塞罗宁,Reverse T3,rT3,3,3’,5’-T3
化学名2-amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl)propanoic acid
Canonical SMILESO=C(O)C(N)CC1=CC=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1
分子式C15H12I3NO4
分子量651.0
溶解度≥ 32.55mg/mL in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

3,3',5'-triiodo-L-thyronine (reverse T3 or rT3) and 3,5,3'-triiodo-L-thyronine (T3) are the metabolism of thyroxine (T4) [1]. 3,3',5'-Triiodo-L-thyronine is thyroid hormone receptors TRα and TRβ antagonist [1].

Thyroid hormones play important roles in the development of the mammalian brain by acting on migration and differentiation of neural cells, synaptogenesis, and myelination. The actions of thyroid hormones are mediated by nuclear thyroid hormone receptors (TRs) and regulation of gene expression. TRs have been also involved in adult brain function. In adult mice, TRα1 deletion and a dominant negative mutant receptor expression induce consistent behavioral changes leading to severe anxiety and morphological changes in the hippocampus [2].

The rT3 was about 1,000-fold less active at the thyroid hormone receptors TRα and TRβ compared with 3,3',5-triiodo-L-thyronine and commonly described as inactive [1].It has been reported that rT3 activates a native form of TRα, TRΔα1, which lacks a nuclear localization signal and functions in the cytoplasm. Through this action, rT3 initiates actin polymerization, particularly in astrocytes and neurons [3].

References:
[1] Nicod P, Burger A, Staeheli V, et al. A radioimmunoassay for 3, 3′, 5′-triiodo-L-thyronine in unextracted serum: method and clinical results[J]. The Journal of Clinical Endocrinology & Metabolism, 1976, 42(5): 823-829.
[2] Bernal J. Thyroid hormone receptors in brain development and function[J]. Nature clinical practice Endocrinology & metabolism, 2007, 3(3): 249-259.
[3] Senese R, Cioffi F, De Lange P, et al. Thyroid: biological actions of ‘nonclassical’thyroid hormones[J]. Journal of Endocrinology, 2014, 221(2): R1-R12.