Neuropeptide S (Rat) 是以前孤儿 G 蛋白偶联受体的内源性配体，现在称为 NPS 受体。
| Cas No. | 412938-75-1 |
| 化学名 | L-seryl-L-phenylalanyl-L-arginyl-L-asparaginylglycyl-L-valylglycyl-L-serylglycyl-L-valyl-L-lysyl-L-lysyl-L-threonyl-L-seryl-L-phenylalanyl-L-arginyl-L-arginyl-L-alanyl-L-lysyl-L-glutamine |
| 分子式 | C95H160N34O27 |
| 分子量 | 2210.5 |
| 溶解度 | Water: 1 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Neuropeptide S is a neuropeptide that is an agonist of the neuropeptide S receptor (NPSR) with an EC50 value of 3.2 nM for the rat peptide to induce intracellular calcium mobilization in HEK293 cells expressing the human receptor. In rats, it increases the duration of wakefulness and decreases slow wave sleep stage 1 (SWS1), SWS2, and rapid eye movement (REM). Neuropeptide S dose-dependently (0.5-4 nmol per animal, i.c.v.) decreases fecal pellet excretion induced by restraint stress or corticotropin releasing factor (CRF) but does not influence basal gastric emptying, gastrointestinal transit, or distal colon propulsion. It also inhibits audible and ultrasonic vocalizations and increases the percentage of time spent in the open arm of the elevated plus maze test in a mouse model of arthritis. |
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