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6β-hydroxy Dexamethasone
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
6β-hydroxy Dexamethasone图片
CAS NO:55879-47-5
包装与价格：
包装价格(元)
500μg电议
1mg电议

产品介绍
Cas No.55879-47-5
别名6-羟基地塞米松
化学名9-fluoro-6β,11β,17,21-tetrahydroxy-16α-methyl-pregna-1,4-diene-3,20-dione
Canonical SMILESO=C1C=C[C@@]2(C)C([C@H](O)C[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@@H](C)[C@]4(O)C(CO)=O)=C1
分子式C22H29FO6
分子量408.5
溶解度Methanol: slightly soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

6β-hydroxy Dexamethasone is a metabolite of dexamethasone that is more hydrophilic than the parent compound. Dexamethasone is metabolized by CYP3A4; therefore, quantification of the dexamethasone metabolites, 6α- and 6β-hydroxy dexamethasone, can be used to determine CYP3A4 enzyme activity in humans., The formation of 6-hydroxy dexamethasone metabolites is species-specific, with hamsters producing the highest amount. In rats, dexamethasone hydroxylation is sex-specific, with male rats producing metabolites in similar ratios to humans and female rats producing fewer hydroxylated metabolites than male rats.

References:
[1].Minagawa, K., Kasuya, Y., Baba, S., et al. Identification and quantification of 6 beta-hydroxydexamethasone as a major urinary metabolite of dexamethasone in man Steroids 47(2-3), 175-188 (1986).
[2].Gentile, D.M., Tomlinson, E.S., Maggs, J.L., et al. Dexamethasone metabolism by human liver in vitro. Metabolite identification and inhibition of 6-hydroxylation J. Pharmacol. Exp. Ther. 277(1), 105-112 (1996).
[3]. Zurbonsen, K., Bressolle, F., Solassol, I., et al. Simultaneous determination of dexamethasone and 6β-hydroxydexamethasone in urine using solid-phase extraction and liquid chromatography: Applications to in vivo measurement of cytochrome P450 3A4 activity J. Chomatogr. B Analyt. Technol. Biomed. Life Sci. 804(2), 421-429 (2004).
[4].Tomlinson, E.S., Maggs, J.L., Park, B.K., et al. Dexamethasone Metabolism in vitro: Species differences J. Steroid Biochem. Mol. Biol. 62(4), 345-352 (1997).