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Tandospirone hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tandospirone hydrochloride图片
CAS NO:99095-10-0
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
Tandospirone (SM-3997) hydrochloride 是一种有效的选择性 5-HT1A 受体部分激动剂,Ki 为 27 nM。
Cas No.99095-10-0
别名SM-3997 hydrochloride
Canonical SMILES[H][C@]13[C@](C(N(CCCCN4CCN(C5=NC=CC=N5)CC4)C3=O)=O)([H])[C@@H]2CC[C@H]1C2.Cl
分子式C21H29N5O2.HCl
分子量419.95
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

5-HT1A receptor partial agonist (Ki = 27 nM) that displays selectivity over 5-HT2, 5-HT1C, α1, α2, D1 and D2 receptors (Ki values ranging from 1300 - 41000 nM). Inactive at 5-HT uptake sites, 5-HT1B, β-adrenergic, muscarinic and benzodiazepine receptors. Displays anxiolytic activity.

Hamik et al (1990) Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites. Biol.Psychiatry 28 99 PMID:1974152 |Pollard et al (1992) Effects of tandospirone in three behavioral tests for anxiolytics. Eur.J.Pharmacol. 221 297 PMID:1358655 |Matsubara et al (2006) Tandospirone, a 5-HT1A agonist, ameliorates movement disorder via non-DArgic systems in rats with unilateral 6-hydroxyDA-generated lesions. Brain Res. 1112 126 PMID:16884702