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CATPB
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CATPB图片
CAS NO:1322598-09-3
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
CATPB 是一种有效的选择性游离脂肪酸受体 2 (FFA2R/GPR43) 拮抗剂。
Cas No.1322598-09-3
Canonical SMILESOC(C[C@@H](NC(CC1=CC=CC(Cl)=C1)=O)CC2=CC=C(C(F)(F)F)C=C2)=O
分子式C19H17ClF3NO3
分子量399.79
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

FFA2 inverse agonist (pKi = 7.87). Selective for human over mouse FFA2. Increases forskolin-induced cAMP production and inhibits acetate-induced MAPK signaling in cells expressing human FFA2.

Park et al (2016) Selective novel inverse agonists for human GPR43 augment GLP-1 secretion. Eur.J.Pharmacol. 771 1 PMID:26683635 |Sergeev et al (2016) Non-equivalence of key positively charged residues of the free fatty acid 2 receptor in the recognition and function of agonist versus antagonist ligands. J.Biol.Chem. 291 303 PMID:26518871