| CAS NO: | 1804978-82-2 |
| 包装: | 10mg |
| 市场价: | 4101元 |
| Cas No. | 1804978-82-2 |
| Canonical SMILES | COC1=C(S(=O)(NC2=CC(NCCNC(C3=C(N(C)C)C=CC=C3)=O)=CC=C2)=O)C=C(C4=CC(C(N(C)C)=O)=CC=C4)C=C1.Cl.Cl |
| 分子式 | C33H37N5O5S.2HCl |
| 分子量 | 688.66 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Potent and selective orexin OX2 receptor agonist (EC50 = 28 nM at human OX2 expressed in CHO cells). Displays approximately 100-fold selectivity for OX2 over OX1 (EC50 = 2.75 μM at human OX1 expressed in CHO cells). Depolarizes OX2-expressing histaminergic neurons in mouse brain slices. Increases wake time in wild type mice. Suppresses cataplexy-like symptoms in OX knockout mice. Nagahara et al (2015) Design and synthesis of non-peptide, selective orexin receptor 2 agonists. J.Med.Chem. 58 7931 PMID:26267383 |Irukayama-Tomobe et al (2017) Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models. Proc.Natl.Acad.Sci.USA. 144 5731 PMID:28507129 |
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