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NS 1643
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NS 1643图片
CAS NO:448895-37-2
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
10mg电议
50mg电议

产品介绍
NS 1643 是人 ether-a-go-go-related gene (hERG) K(+) 通道的部分激动剂,EC50 为 10.5 μM。
Cas No.448895-37-2
化学名1,3-bis(2-hydroxy-5-(trifluoromethyl)phenyl)urea
Canonical SMILESFC(F)(C(C=C1)=CC(NC(NC(C=C(C(F)(F)F)C=C2)=C2O)=O)=C1O)F
分子式C15H10F6N2O3
分子量380.24
溶解度≥ 13.05mg/mL in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

NS1643 is a partial agonist of human ether-a-go-go-related gene (hERG) K(+) channels with an EC50 of 10.5 μM. NS1643 has distinct effects on erg2 (Kv11.2) currents by reducing channel inactivation especially at high concentrations[1]. NS1643 increases the repolarization reserve and exhibits an interesting new antiarrhythmic approach[2].

References:
[1]. Sun XJ, et al. The Role of Histone Acetyltransferases in Normal and Malignant Hematopoiesis. Front Oncol. 2015 May 26;5:108.
[2]. Casis O, et al. Mechanism of action of a novel human ether-a-go-go-related gene channel activator. Mol Pharmacol. 2006 Feb;69(2):658-65. Epub 2005 Nov 11.