6α-羟基紫杉醇是紫杉醇的主要代谢物。 6α-羟基紫杉醇保留对有机阴离子转运多肽 1B1/SLCO1B1 (OATP1B1) 的时间依赖性作用，具有与紫杉醇相似的抑制效力，而它不再显示对 OATP1B3 的时间依赖性抑制。 6α-羟基紫杉醇可用于癌症的研究。
| Cas No. | 153212-75-0 |
| 别名 | 6-羟基泰素 |
| Canonical SMILES | O[C@@H](C(O[C@H]1C[C@]([C@H]2OC(C3=CC=CC=C3)=O)(O)C(C)(C)C([C@@H](OC(C)=O)C([C@@]4(C)[C@@]2([H])[C@](OC(C)=O)(CO5)[C@H]5[C@@H](O)[C@@H]4O)=O)=C1C)=O)[C@@H](NC(C6=CC=CC=C6)=O)C7=CC=CC=C7 |
| 分子式 | C47H51NO15 |
| 分子量 | 869.9 |
| 溶解度 | DMSO: 30 mg/ml,Methanol: 10 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 6α-hydroxy Paclitaxel is a primary metabolite of the anticancer compound paclitaxel , produced by the action of the cytochrome P450 isoform CYP2C8. The generation of 6α-hydroxy paclitaxel by CYP2C8 can be impacted by other drugs or dietary components that interefere with CYP2C8 activity, as well as by CYP2C8 genetic polymorphisms. |
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