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Cylindrospermopsin
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Cylindrospermopsin图片
CAS NO:143545-90-8
包装与价格：
包装价格(元)
25μg电议
50μg电议
100μg电议
500μg电议

产品介绍
Cas No.143545-90-8
别名柱孢藻毒素
化学名6-[(R)-hydroxy[(2aS,3R,4S,5aS,7R)-2,2a,3,4,5,5a,6,7-octahydro-3-methyl-4-(sulfooxy)-1H-1,8,8b-triazaacenaphthylen-7-yl]methyl]-2,4(1H,3H)-pyrimidinedione
Canonical SMILESC[C@H]1[C@@H](OS(=O)(O)=O)C[C@@]2([H])N(C3=N[C@]([C@@H](O)C(N([H])C(N4[H])=O)=CC4=O)([H])C2)[C@@]1(CN3)[H]
分子式C15H21N5O7S
分子量415.4
溶解度Soluble in DMSO, Methanol, Water
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Cylindrospermopsin, a tricyclic uracil derivative, is a cyanobacterial toxin that was first discovered in an algal bloom contaminating a local drinking supply on Palm Island in Queensland, Australia after an outbreak of a mysterious disease. Cylindrospermopsin targets protein and glutathione synthesis in hepatocytes (IC50s = 1.3 and 2.4 &#181M, respectively), leading to cell death. [1] It has been shown to inhibit the activity of the uridine monophosphate synthase complex with a Ki value of 10 &#181M.[2] Cylindrospermopsin is genotoxic, inducing DNA damage as evidenced by double strand breaks and reducing cell viability in HepG2 cells at 0.1-0.5 &#181g/ml.[3]

Reference:
[1]. Runnegar, M.T., Xie, C., Snider, B.B., et al. In vitro hepatotoxicity of the cyanobacterial alkaloid cylindrospermopsin and related synthetic analogues. Toxicological Sciences 67, 81-87 (2002).
[2]. Reisner, M., Carmeli, S., Werman, M., et al. The cyanobacterial toxin cylindrospermopsin inhibits pyrimidine nucleotide synthesis and alters cholesterol distribution in mice. Toxicological Sciences 82, 620-627 (2004).
[3]. Straser, A., Filipic, M., Novak, M., et al. Double strand breaks and cell-cycle arrest induced by the cyanobacterial toxin cylindrospermopsin in HepG2 cells. Mar.Drugs 11(8), 3077-3090 (2013).