| 包装 | 价格(元) |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
Substrate | Aβ40 |
Preparation Method | Aβ40 (30 μM) in pH 7.4 phosphate buffer incubated on a Speci-Mix aliquot mixer. Aβ40 in the presence of 50 ng/mL cholesterol-SO4, 500 μg/mL cholesterol-SO4, 50 ng/mL DC-Chol (hydrochloride), and 500 μg/mL DC-cholesterol |
Reaction Conditions | 50/500 ng/mL DC-Chol (hydrochloride) with Aβ40 for 17h |
Applications | For DC-Chol (hydrochloride), Aβ fibers were observed in the image of Aβ40 (30 μM) coincubated with low concentration of DC-cholesterol (50 ng/mL). However, in the presence of 500 μg/mL DC-cholesterol, no fiber structures were found in the image. |
| 产品描述 | DC-Chol(hydrochloric acid) can inhibit the formation of Aβ40 fibers,DC-Chol(hydrochloric acid) can inhibit the amyloid formation of oxidized hCT[1,2]. For DC-Chol (hydrochloride), Aβ fibers were observed in the image of Aβ40 (30 µM) coincubated with low concentration of DC-Chol (hydrochloride) (50 ng/mL). However, in the presence of 500 µg/mL DC-Chol (hydrochloride), no fiber structures were found in the image[1]. DC-Chol/DOPE cationic liposomes properly condense and compact CT-DNA by means of a strong entropically driven surface electrostatic interaction[3]. Lipoplexes constituted by calf-thymus DNA (CT-DNA) and mixed cationic liposomes consisting of varying proportions of the cationic lipid 3β-[N-(N',N'-dimethylaminoethane)-carbamoyl]cholesterol hydrochloride (DC-Chol (hydrochloride)) and DOPE have been analyzed. DC-Chol/DOPE liposomes, with a mean hydrodynamic diameter of around (120±10) nm, compact and condense DNA fragments at their cationic surfaces by means of a strong entropically driven electrostatic interaction[4]. Formulations prepared with 50 mol% DODAC or DC-Chol (hydrochloride), and 20 mol% DSPE-PEG(2000) exhibited circulation half-lives ranging from 6.5 to 12.5 h. DC-Chol (hydrochloride) formulations prepared with DSPE-PEG(2000) accumulated threefold higher in s.c. HT29 tumors than its PEG-free counterpart[6]. DC-Chol (hydrochloride) is internalized through macrocytosis and clathrin-mediated endocytosis [5]. References: |
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