| CAS NO: | 72571-82-5 |
| 包装 | 价格(元) |
| 1g | 电议 |
| 5g | 电议 |
| 10g | 电议 |
| 25g | 电议 |
| Cas No. | 72571-82-5 |
| 别名 | 吡哌酸三水合物 |
| Canonical SMILES | O=C(C1=CN(CC)C2=NC(N3CCNCC3)=NC=C2C1=O)O.O.O.O |
| 分子式 | C14H17N5O3•3H2O |
| 分子量 | 357.4 |
| 溶解度 | DMF: 0.50 mg/ml,DMSO: 1 mg/ml,DMSO:PBS (pH 7.2) (1:4): 0.20 mg/ml |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Pipemidic acid is an antibiotic and derivative of piromidic acid .1It is active against clinical isolates ofE. coli, P. mirabilis, P. inconstans, Shigella, Salmonella, Alcaligenes, andV. parahaemolyticus(MICs = 0.78-100 µg/ml), as well as drug-resistant clinical isolates ofE. coli, P. mirabilis, Klebsiella, andShigella(MICs = 1.56-6.25 µg/ml). Pipemidic acid is protective against systemicS. aureus, E. coli, K. pneumoniae, andP. aeruginosainfections in mice (ED50s = 237.5, 204.1, 28.6, and 99.5 mg/kg, respectively).2It is also protective againstP. aeruginosa-induced pulmonary and dermal infections (ED50s = 81.7 and 173.2 mg/kg, respectively), as well asE. coli, K. pneumoniae, andP. aeruginosaurinary bladder infections (ED50s = 4.8, 11.9, and 30.6 mg/kg, respectively), in mice. 1.Shimizu, Y., Takase, Y., Nakamura, S., et al.Pipemidic acid, a new antibacterial agent active against Pseudomonas aeruginosa: In vitro propertiesAntimicrob. Agents Chemother.8(2)132-138(1975) 2.Shimizu, M., Takdase, Y., Nakamura, S., et al.Pipemidic acid: Its activities against various experimental infectionsAntimicrob. Agents Chemother.9(4)569-574(1976) |
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