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Penconazole
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Penconazole图片
CAS NO:66246-88-6
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
100mg电议
250mg电议

产品介绍
Penconazole是一种典型的三唑类杀菌剂(fungicide),主要用于苹果、葡萄、蔬菜等地的白粉病防治。Penconazole抑制真菌固醇生物合成。Penconazole降低大鼠大脑和小脑AChE活性。
Cas No.66246-88-6
别名戊菌唑
Canonical SMILESCCCC(C1=CC=C(Cl)C=C1Cl)CN2N=CN=C2
分子式C13H15Cl2N3
分子量284.18
溶解度DMSO: 100 mg/mL (351.89 mM)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats[1][2].

Penconazole (67 mg/kg; i.p.; every 2 days during 9 days) induces oxidative stress in rat cerebrum and cerebellum tissues[2].Penconazole has the ability to induce oxidative damage in the brain of adult rats, as evidenced by an increase of lipid peroxidation and protein oxidation, in addition to the perturbations in the enzymatic and nonenzymatic antioxidant status. Penconazole also affects the cholinergic system, activities of membrane-bound ATPases, and brain histoarchitecture. Penconazole is a potential neurotoxicant pesticide that exerts its neurotoxic effects via the generation of oxidative stress. Penconazole causes a significant inhibition of AChE activity in the cerebrum (11%) and cerebellum (25%) of adult rats[2]. Animal Model: Twelve male Wistar rats[2]

[1]. Husak VV, et al. Acute exposure to the penconazole-containing fungicide Topas partially augments antioxidant potential in goldfish tissues. Comp Biochem Physiol C Toxicol Pharmacol. 2017;193:1-8. [2]. ChaÂbane M, et al. Penconazole alters redox status, cholinergic function, and membrane-bound ATPases in the cerebrum and cerebellum of adult rats. Hum Exp Toxicol. 2017;36(8):854-866.