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2'-Deoxy-2'-fluorocytidine
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
2'-Deoxy-2'-fluorocytidine图片
CAS NO:10212-20-1
包装与价格：
包装价格(元)
10mM (in 1mL Water)电议
100mg电议

产品介绍
2'-Deoxy-2'-fluorocytidine是一种核苷类似物，是刚果出血热病毒(CCHFV)复制的有效抑制剂。2'-Deoxy-2'-fluorocytidine可与T705协同作用，增强两种化合物对CCHFV复制的抗病毒效力。
Cas No.10212-20-1
别名2'-脱氧-2-氟胞苷
Canonical SMILESF[C@H]1[C@@](N2C(N=C(C=C2)N)=O)([H])O[C@@H]([C@H]1O)CO
分子式C9H12FN3O4
分子量245.21
溶解度Water: 5 mg/mL (20.39 mM; ultrasonic and warming and heat to 60°C)
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

2'-Deoxy-2'-fluorocytidine, an nucleoside analog, is a potent inhibitor of Crimean-Congo hemorrhagic fever virus (CCHFV) replication. 2′-deoxy-2′-fluorocytidine can act synergistically with T705 to increase the potency of both compounds antiviral effects on CCHFV replication[1].

2'-Deoxy-2'-fluorocytidine has antiviral activities, showing 50% effective concentrations (EC50) of 61 nM and 31 nM against CCHFV and CCHFV/ZsG in Huh7 cells, respectively. And it shows a 50% cytotoxicity concentration (CC50) of >50.0 μM in Huh7 cells[1].

[1]. Stephen R Welch, et al. Identification of 2'-deoxy-2'-fluorocytidine as a potent inhibitor of Crimean-Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus. Antiviral Res. 2017 Nov;147:91-99.