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Artemisinine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Artemisinine图片
CAS NO:63968-64-9
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
200mg电议
500mg电议

产品介绍
青蒿素(青蒿素)是一种倍半萜内酯,是一种从青蒿地上部分中分离得到的抗疟药。
Cas No.63968-64-9
别名青蒿素; Qinghaosu; NSC 369397
化学名(5aS,6R,8aS,9R,12S,12aR)-3,6,9-trimethyloctahydro-3H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10(12H)-one
Canonical SMILESO=C1O[C@]2([H])OC3(C([H])([H])[H])OO[C@]42[C@](C([H])([H])C3([H])[H])([H])[C@@](C([H])([H])[H])([H])C([H])([H])C([H])([H])[C@@]4([H])[C@@]1([H])C([H])([H])[H]
分子式C15H22O5
分子量282.33
溶解度≥ 13.7mg/mL in DMSO
储存条件Store at 2-8°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial drug isolated from the aerial parts of Artemisia annua L. plants[1]. Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects[2].

Artemisinin (Qinghaosu) (25 or 50 μM; 24 hours) concentration-dependently suppresses Aβ25-35 induced cytotoxicity in PC12 cells[1]. Artemisinin (1-100 μM; 24 hours) selectively inhibits cancer cell growth in a dose-dependent manner with IC50 values of 31.30 ± 0.73 μM in UMRC-2 cells and 23.97 ± 0.92 CAKI-2 cells[2]. Artemisinin (25, 50 μM; 24 hours) suppresses the phosphorylation of AKT in UMRC-2 and CAKI-2 cells in a dose-dependent manner[2].

Artemisinin (gavage; 20 mg/kg/day; for two weeks) suppresses UMRC-2 xenograft tumor growth[2].

References:
[1]. Zeng Z, et al. Artemisinin protects PC12 cells against β-amyloid-induced apoptosis through activation of the ERK1/2 signaling pathway. Redox Biol. 2017 Apr 4;12:625-633.
[2]. Lin SP, et al. Artemisinin Prevents Glutamate-Induced Neuronal Cell Death Via Akt Pathway Activation. Front Cell Neurosci. 2018 Apr 20;12:108.