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9-Hydroxyellipticine(hydrochloride)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
9-Hydroxyellipticine(hydrochloride)图片
CAS NO:52238-35-4
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
9-Hydroxyellipticine (hydrochloride) 是 Topo II 和 RyR 的抑制剂。
Cas No.52238-35-4
Canonical SMILESCC1=C2C(NC3=C2C=C(O)C=C3)=C(C)C4=C1C=NC=C4.Cl
分子式C17H14N2O.HCl
分子量298.8
溶解度DMSO: slightly, heated,Methanol: slightly
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

9-Hydroxyellipticine is a derivative of ellipticine with diverse biological activities.1,2,3 It inhibits aroclor-induced activation of aniline hydroxylase, aminopyrine N-demethylase, and 7-ethoxycourmarin O-deethylase in rat liver microsomes (Kis = 3.5, 0.6, and 0.74 μM, respectively).1 9-Hydroxyellipticine inhibits the growth of L1210 murine leukemia cells (IC50 = 3 nM) in vitro and increases survival in an L1210 mouse leukemia model.2,3 It inhibits carrageenan-induced edema and UV-induced erythema in guinea pigs.4

References
1. Lesca, P., Rafidinarivo, E., Lecointe, P., et al. A class of strong inhibitors of microsomal monooxygenases: The ellipticines. Chem. Biol. Interact. 24(2), 189-197 (1979).
2. Monnot, M., Mauffret, O., Simon, V., et al. DNA-drug recognition and effects on topoisomerase II-mediated cytotoxicity. A three-mode binding model for ellipticine derivatives. J. Biol. Chem. 266(3), 1820-1829 (1991).
3. Le Pecq, J.B., Grosse, C., Dat-Xuong, N., et al. Antitumor activity of 9-hydroxyellipticine (NSC 210717) ON L1210 mouse leukemia and the effect of route of injection. Cancer Res. 36(9 pt. 1), 3067-3076 (1976).
4. Cros, J., Thibault, A., and Dat-Xuong, N. Anti-inflammatory effect of hydroxy-9-ellipticine. C. R. Acad. Sci. Hebd. Seances Acad. Sci. D. 281(15), 1139-1142 (1975).