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GRL0617
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GRL0617图片
CAS NO:1093070-16-6
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议

产品介绍
GRL0617 是一种强效、选择性和竞争性的 SARS-CoV PLpro/deubiquitinase 的非共价抑制剂,其 IC50 值为 0.6 μM,Ki 值为 0.49 μM.
Cas No.1093070-16-6
Canonical SMILESO=C(N[C@@H](C1=C2C=CC=CC2=CC=C1)C)C3=CC(N)=CC=C3C
分子式C20H20N2O
分子量304.39
溶解度DMSO: 125 mg/mL (410.66 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

GRL0617 is a potent, selective and competitive noncovalent inhibitor of severe acute respiratory syndrome (SARS-CoV) papain-like protease (PLpro)/deubiquitinase, with an IC50 of 0.6 μM, and with a Ki of 0.49 μM[1].

[1]. Ratia K, et al. A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16119-24.