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ML 315 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ML 315 hydrochloride图片
CAS NO:1440251-53-5
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
Inhibitor of Clk and DYRK kinases
Cas No.1440251-53-5
Canonical SMILESClC1=CC(CNC2=NC=NC=C2C3=CC=C(OCO4)C4=C3)=CC(Cl)=C1.Cl
分子式C18H13Cl2N3O2.HCl
分子量410.68
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Inhibitor of cdc2-like kinases (Clk) and DYRK kinases (IC50 values are 68, 68 and 231 nM for Clk1, Clk4 and Clk2, respectively, and 282 and 1156 nM for Dyrk1A and Dyrk1B). Shows 20-fold selectivity for Clk4 over Dyrk1A. Stable in both mouse and human plasma. Moderately cell permeable.

Coombs et al (2013) Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315. Bioorg.Med.Chem.Lett. 23 3654 PMID:23642479