N-Nitroso-N-methylurea

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

684-93-5

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议

产品介绍

N-Nitroso-N-methylurea (NMU;MNU;NMH) 是一种有效的致癌剂，诱变剂和致畸剂。N-Nitroso-N-methylurea 是一种直接作用的烷基化剂，与 DNA 相互作用。N-Nitroso-N-methylurea 靶向多种动物器官，以引起各种癌症和/或变性疾病。N-Nitroso-N-methylurea 也是一种重氮甲烷合成中的前体物质。

Cas No.	684-93-5
别名	1-甲基-1-亚硝基脲,NMU; MNU; NMH
Canonical SMILES	O=C(N)N(C)N=O
分子式	C₂H₅N₃O₂
分子量	103.08
溶解度	DMSO: 125 mg/mL (1212.65 mM)
储存条件	4°C, protect from light, stored under nitrogen
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	N-Nitroso-N-methylurea (NMU;MNU;NMH) is a potent carcinogen, mutagen and teratogenand. N-Nitroso-N-methylurea is a direct-acting alkylating agent that interacts with DNA. N-Nitroso-N-methylurea targets multiple animal organs to cause various cancer and/or degenerative disease. N-Nitroso-N-methylurea is also a precursor in the synthesis of diazomethane[1][2][3][4]. [1]. Gullino PM, et al. N-nitrosomethylurea as mammary gland carcinogen in rats. J Natl Cancer Inst. 1975 Feb;54(2):401-14. [2]. Tsubura A, et al. Review: Animal models of N-Methyl-N-nitrosourea-induced mammary cancer and retinal degeneration with special emphasis on therapeutic trials. In Vivo. 2011 Jan-Feb;25(1):11-22. [3]. Johnson EM, et al. Effects of N-nitroso-N-methylurea on enzymatic ontogeny associated with teratogenesis. Teratology. 1968 May;1(2):179-91. [4]. Silvia Garbarino, et al. One-pot synthesis of α-haloketones employing a membrane-based semibatch diazomethane generator. Journal of Flow Chemistry volume 6, pages211-217(2016). [5]. Moon KY. N-nitroso-N-methylurea and N-nitroso-N-ethylurea induce upregulation of cellular NF-kappa B activity through protein kinase C-dependent pathway in human malignant keratinocytes. Arch Pharm Res. 2010 Jan;33(1):133-9.