| CAS NO: | 1357349-91-7 |
| 包装: | 5mg |
| 市场价: | 1080元 |
| Cas No. | 1357349-91-7 |
| Canonical SMILES | CC(C)N1C2=NC=NC(N)=C2C(C#CC3=CC=CC=C3)=N1 |
| 分子式 | C16H15N5 |
| 分子量 | 277.32 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | SPP-86 is a potent and selective cell permeable inhibitor of RET tyrosine kinase, with an IC50 of 8 nM. SPP-86 selectively inhibits RET- induced ERK1/2 phosphorylation in thyroid cancer cell lines[1]. IC50: 8 nM (RET)[1]. [1]. Alao JP, et al. Selective inhibition of RET mediated cell proliferation in vitro by the kinase inhibitor SPP86. BMC Cancer. 2014 Nov 20;14:853. |
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