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Polyphyllin A
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Polyphyllin A图片
CAS NO:50773-41-6
包装:20mg
市场价:1620元

产品介绍
Polyphyllin A是从巴黎复叶植物中提取的一种生物活性成分，具有很强的抗肿瘤活性。 Polyphyllin A 是 JNK 信号通路的激活剂，是 PDK1/Akt/mTOR 信号通路的抑制剂。 Polyphyllin A 诱导自噬、G2/M 期阻滞和细胞凋亡。
Cas No.50773-41-6
别名重楼皂苷I
化学名Chonglou saponin I
Canonical SMILESO[C@@H]1[C@@H](O)[C@H](CO)O[C@@]1([H])O[C@H]2[C@H](O)[C@@H](O[C@@]3([H])[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O3)C(O[C@H]4CC5=CC[C@]([C@@](C[C@@]6([H])[C@]7([H])[C@H](C)[C@]8(OC[C@H](C)CC8)O6)([H])[C@]7(C)CC9)([H])[C@@]9([H])[C@@]5(C)CC4)O[C@@H]2CO
分子式C44H70O16
分子量855.02
溶解度≥ 42.75mg/mL in EtOH with ultrasonic and warming
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Polyphyllin I is a bioactive constituent extracted from Paris polyphylla, has strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and is an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis[1][2][3].

References:
[1]. Kong M, et al. Effects of polyphyllin I on growth inhibition of human non-small lung cancer cells and in xenograft. Acta Biochim Biophys Sin (Shanghai). 2010 Nov;42(11):827-33.
[2]. Liu J, et al. Polyphyllin I induces G2/M phase arrest and apoptosis in U251 human glioma cells via mitochondrial dysfunction and the JNK signaling pathway. Acta Biochim Biophys Sin (Shanghai). 2017 Jun 1;49(6):479-486.
[3]. He J, et al. Polyphyllin I induces autophagy and cell cycle arrest via inhibiting PDK1/Akt/mTOR signal and downregulating cyclin B1 in human gastric carcinoma HGC-27 cells. Biomed Pharmacother. 2019 Sep;117:109189.