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Taurodeoxycholic Acid-d4 MaxSpec® Standard
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Taurodeoxycholic Acid-d4 MaxSpec® Standard图片
CAS NO:1332881-65-8
包装:100µg
市场价:4007元

产品介绍
A quantitative analytical standard guaranteed to meet MaxSpec®identity, purity, stability, and concentration specifications
Cas No.1332881-65-8
Canonical SMILESO[C@@H]1C([2H])([2H])C[C@@]2(C)[C@@](CC[C@]3([H])[C@]2([H])C[C@H](O)[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCC(NCCS(=O)(O)=O)=O)([H])C1([2H])[2H]
分子式C26H41D4NO6S
分子量503.7
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Taurodeoxycholic acid-d4(TDCA-d4) is intended for use as an internal standard for the quantification of taurodeoxycholic acid by GC- or LC-MS. TDCA is a taurine-conjugated form of the secondary bile acid deoxycholic acid .1TDCA stimulates chloride ion secretion through calcium-activated chloride ion channels and cystic fibrosis transmembrane conductance regulator (CFTR) in Calu-3 airway epithelial cell monolayers when applied basolaterally.2Serum levels of taurodeoxycholic acid increase approximately 5-fold within two hours during an oral lipid tolerance test in humans.1

TDCA-d4MaxSpec®standard is a quantitative grade standard of TDCA-d4that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. The verified concentration is provided on the certificate of analysis. This TDCA-d4MaxSpec®standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product.Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

1.Schmid, A., Neumann, H., Karrasch, T., et al.Bile acid metabolome after an oral lipid tolerance test by liquid chromatography-tandem mass spectrometry (LC-MS/MS)PLoS One11(2)e0148869(2016) 2.Hendrick, S.M., Mroz, M.S., Greene, C.M., et al.Bile acids stimulate chloride secretion through CFTR and calcium-activated Cl- channels in Calu-3 airway epithelial cellsAm. J. Physiol. Lung. Cell. Mol. Physiol.307(5)L407-L418(2014)