HDAC6 Inhibitor 是一种有效的选择性 HDAC6 抑制剂 (IC50=36 nM)。 HDAC6 Inhibitor 弱抑制其他 HDAC 同工型。 HDAC6 Inhibitor 抑制细胞中的酰基微管蛋白积累，IC50 值为 210 nM。
| Cas No. | 1259296-46-2 |
| Canonical SMILES | O=C(NO)C1=CC(CCN(C(C2=CC=CN2C)=O)C3)=C3C=C1 |
| 分子式 | C16H17N3O3 |
| 分子量 | 299.3 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | HDAC6 is a predominantly cytoplasmic enzyme that targets α-tubulin, cortactin, and heat shock protein 90, as well as other substrates. In this way, it impacts development, proliferation, invasion, and tumorigenesis. HDAC6 Inhibitor is a potent and selective inhibitor of HDAC6 (IC50 = 36 nM) that poorly blocks other HDAC enzymes. It is cell permeable, inhibiting the acetylation of tubulin in cells with an IC50 value of 210 nM. |
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