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GSK121(trifluoroacetate salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GSK121(trifluoroacetate salt)图片
CAS NO:1652591-80-4
包装与价格:
包装价格(元)
500μg电议
1mg电议
5mg电议
10mg电议

产品介绍
GSK-121 Trifluoroacetates 是一种选择性 PAD4 抑制剂。
Cas No.1652591-80-4
Canonical SMILESNC1CN(C(C2=CC(N=C(C3=CC(C=CC=C4)=C4N3C)N5C)=C5C=C2)=O)CCC1.FC(F)(C(O)=O)F
分子式C23H25N5O•CF3COOH
分子量501.5
溶解度DMF: 30 mg/ml,DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml,PBS (pH 7.2): 10 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Protein arginine deiminase 4 (PAD4) mediates the transformation of protein arginine into citrulline. Citrullination of proteins has normal roles in gene regulation and pathological roles in immunological and inflammatory diseases. GSK121 is the initial compound identified in a screen for PAD4 inhibitors and was optimized to produce the more potent PAD4 inhibitors, GSK484 and GSK199 . GSK121 was shown to inhibit the citrullination of PAD4 target proteins in a functional assay with an IC50 value of 3.2 µM.