| CAS NO: | 2205018-06-8 |
| 包装: | 1mg |
| 市场价: | 2646元 |
| Cas No. | 2205018-06-8 |
| Canonical SMILES | O=C(/C=C/[C@@H](O)[C@H](C)O1)O[C@@H](C)CC[C@H](O)/C=C/C1=O |
| 分子式 | C14H20O6 |
| 分子量 | 284.3 |
| 溶解度 | Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Clonostachydiol is a fungal metabolite originally isolated fromClonostachys cylindrosporathat has anticancer and anthelmintic activities.1,2It is cytotoxic to P388 (IC50= 25 µM), as well as L1210, HT-29, and A549 cancer cells (IC50s = 4.5, 4.2, and 5.7 µg/ml, respectively). Clonostachydiol (2.5 mg/kg, s.c.) reduces fecal worm burden by 80 to 90% in lambs infected with the nematodeH. contortus.1 1.Grabley, S., Hammann, P., Thiericke, R., et al.Secondary metabolites by chemical screening. 21. Clonostachydiol, a novel anthelmintic macrodiolide from the fungus Clonostachys cylindrospora (strain FH-A 6607)J. Antibiot. (Tokyo)46(2)343-345(1993) 2.Lang, G., Mitova, M.I., Ellis, G., et al.Bioactivity profiling using HPLC/microtiter-plate analysis: Application to a New Zealand marine alga-derived fungus, Gliocladium spJ. Nat. Prod.69(4)621-624(2006) |
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