| CAS NO: | 1189877-11-9 |
| 包装: | 1mg |
| 市场价: | 4158元 |
| Cas No. | 1189877-11-9 |
| 别名 | Methforylthiazidine-13C,d2; Rontyl-13C,d2 |
| Canonical SMILES | O=S1(C2=C(C=C(C(F)(F)F)C(S(N)(=O)=O)=C2)N[13C]([2H])([2H])N1)=O |
| 分子式 | C7[13C]H6D2F3N3O4S2 |
| 分子量 | 334.3 |
| 溶解度 | DMSO: Soluble,Methanol: Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Hydroflumethiazide-13C-d2is intended for use as an internal standard for the quantification of hydroflumethiazide by GC- or LC-MS. Hydroflumethiazide is a thiazide diuretic and an inhibitor of carbonic anhydrase (CA).1It is selective for CAII, CAVB, CAVII, CAIX, CAXII, and CAXIV (Kis = 0.24-0.31 µM) over CAI, CAIV, and CAVI (Kis = 2.8-8.3 µM), as well as CAIII, CAVA, and CAXIII (Kis = >10 µM). Formulations containing hydroflumethiazide have been used in the treatment of hypertension. 1.Temperini, C., Cecchi, A., Scozzafava, A., et al.Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adductBioorg. Med. Chem. Lett.18(8)2567-2573(2008) |
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