| CAS NO: | 15489-90-4 |
| 包装: | 100mg |
| 市场价: | 360元 |
| Cas No. | 15489-90-4 |
| 别名 | 羟高铁血红素 |
| 分子式 | C34H33FeN4O5 |
| 分子量 | 633.49 |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Hematin, an iron-containing porphyrin, inhibits the activity of clotting factors and also fibrin clot lysis through the mechanism of binding to and inactivation of hemostatic proteins[1]. Hematin can be used for the research of acute porphyrias and cancer[1][2][3][4][5]. Hematin (0.01 mg/ml) inhibits the clotting of bovine fibrinogen (1.3 to 2.6 mg/ml) by bovine thrombin (0.12 U/ml) and inhibits the hydrolysis of a synthetic substrate by human thrombin[2].Hematin (0.035 mg/ml) reduces VIII:C activity from 0.88 to 0.40 U/ml[2].Hematin (0.05 mg/ml) inhibits the activation of VIII:C by thrombin (0.04 U/ml)[2].Hematin (0.09 mg/ml) inhibits the hydrolysis of a synthetic substrate by plasmin[2]. Hematin (i.v.; single injection) suppressed porphyrin production in SD rat (weighing 160-205 g)[4]. [1]. Siegert SW, et al. Physicochemical properties, pharmacokinetics, and pharmacodynamics of intravenous hematin: a literature review. Adv Ther. 2008 Sep;25(9):842-57. |
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