Guanethidine

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Guanethidine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	55-65-2
包装:	500mg
市场价:	1080元

产品介绍

Guanethidine 于1959年合成。它被认为是通过干扰神经节后交感神经纤维中的化学递质物质的代谢来降低血压。

Cas No.

55-65-2

分子式

C₁₀H₂₂N₄

分子量

198.31

储存条件

Store at -20°C

General tips

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

产品描述

Guanethidine sulphate was synthesized in 1959. Guanethidine is thought to lowingblood pressure
by interfering with the metabolism of chemical transmitter substances in post-ganglionic sympathetic nerve fibres.

Ablation of sympathetic fibers is associated with a loss of rat endothelial cell marker (RECA), but no significant effect of guanethidine was found on the survival of endothelial cells and mesenchymal stem cells in vitro^[1].
.

Guanethidine (30 mg/kg, s.c., 1 h) unaffected IL-18 hypernociception in TNFR1^(-/-)mice as a sympathetic blocker^[2].
.

Animal Model:	Wild-type (WT) Balb/c,TNFR1^(-/-)and IFN_-γ-γ^(-/-)mice^[2].
Dosage:	30 mg/kg
Administration:	Guanethidine (30 mg/kg, s.c., 1 h, diluted in saline)
Result:	Pre-treatment with guanethidine (sympathetic blocker) unaffected IL-18 hypernociception in TNFR1^(-/-)mice.