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Ezurpimtrostat hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ezurpimtrostat hydrochloride图片
CAS NO:1914148-73-4
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
Ezurpimtrostat hydrochloride (compound 2-3) 是一种口服有效的抗纤维化剂。Ezurpimtrostat hydrochloride 能明显减轻 DEN (二乙基亚硝胺)肝硬化大鼠的肝纤维化。Ezurpimtrostat hydrochloride 可用于纤维化、癌症、自噬和CTSB、CTSL 和 CTSD 相关的疾病研究。
Cas No.1914148-73-4
别名GNS561 hydrochloride
分子式C25H32Cl2N4
分子量459.45
溶解度DMSO : 8.33 mg/mL (18.13 mM; ultrasonic and warming and heat to 60°C)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Ezurpimtrostat hydrochloride (compound 2-3) is a potent and orally active anti-fibrotic agent. Ezurpimtrostat hydrochloride reduces significantly the liver fibrosis in DEN (diethyl nitrosamine) cirrhotic rat model. Ezurpimtrostat hydrochloride can be used for the research of fibrosis, cancer, autophagy and cathepsins B (CTSB), L (CTSL) and D (CTSD) related diseases [1].

Ezurpimtrostat hydrochloride (compound 2-3) (15 mg/kg/day, PO, for 6 weeks) significantly reduces the area of liver fibrosis and the level of collagen fibers deposition (by 41.0%) in DEN cirrhotic rat model[1].

[1]. Philippe Halfon, et al. Substituted 2,4 diamino-quinoline as new medicament for fibrosis, autophagy and cathepsins b (ctsb), l (ctsl) and d (ctsd) related diseases. EP3620164A1.