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6'-Sialyllactose Sodium Salt
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
6'-Sialyllactose Sodium Salt图片
CAS NO:157574-76-0
包装与价格：
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍
6'-唾液酸乳糖（钠）是一种主要的乳寡糖，可减少铜绿假单胞菌在人肺细胞中的内化。
Cas No.157574-76-0
别名6'-唾液乳糖钠盐,6'-N-Acetylneuraminyl-D-lactose
化学名O-(N-acetyl-α-neuraminosyl)-(2→6)-O-β-D-galactopyranosyl-(1→4)-D-glucose, monosodium salt
Canonical SMILESO[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO[C@@]2(C([O-])=O)O[C@]([C@@H]([C@H](O)CO)O)([H])[C@H](NC(C)=O)[C@@H](O)C2)O[C@H]1O[C@@]([C@H](O)CO)([H])[C@H](O)[C@@H](O)C=O.[Na+]
分子式C23H38NNaO19
分子量655.53
溶解度DMSO: 5 mg/ml,PBS (pH 7.2): 10 mg/ml
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

6'-Sialyllactose consists of the monosaccharide N-acetylneuraminic acid linked to the galactosyl subunit of lactose at the 6 position. This connection is at the 3 position in the related compound, 3’-sialyllactose. Both are major milk oligosaccharides that avidly bind several viral strains, including strains of influenza, HIV-1, reovirus, and polyomavirus.[1],[2],[3],[4],[5],[6] These compounds can be used to differentiate and characterize the binding domains of viruses that recognize N-acetylneuraminic acid-capped cell surface receptors. They are also used as analytical reference standards for quantification in samples such as milk or colostrum.

Reference：
[1]. Duncan, P.I., Raymond, F., Fuerholz, A., et al. Sialic acid utilisation and synthesis in the neonatal rat revisited. PLoS One 4(12), 1-10 (2009).
[2]. Sprenger, N., and Duncan, P.I. Sialic acid utilization. Adv.Nutr. 3(3), 392S-397S (2012).
[3]. Iskarpatyoti, J.A., Morse, E.A., McClung, R.P., et al. Serotype-specific differences in inhibition of reovirus infectivity by human-milk glycans are determined by viral attachment protein σ1. Virology 433(2), 489-497 (2012).
[4]. Neu, U., Khan, Z.M., Schuch, B., et al. Structures of B-lymphotropic polyomavirus VP1 in complex with oligosaccharide ligands. PLoS Pathogens 9(10), 1-10 (2013).
[5]. Rosa Borges, A., Wieczorek, L., Johnson, B., et al. Multivalent dendrimeric compounds containing carbohydrates expressed on immune cells inhibit infection by primary isolates of HIV-1. Virology 408(1), 80-88 (2010).
[6]. Wu, W., and Air, G.M. Binding of influenza viruses to sialic acids: Reassortant viruses with A/NWS/33 hemagglutinin bind to α2,8-linked sialic acid. Virology 325(2), 340-350 (2004).