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N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy3
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy3图片
CAS NO:2107273-62-9
包装:1mg
市场价:2259元

产品介绍
N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy3 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。
Cas No.2107273-62-9
分子式C45H65ClN2O10
分子量829.46
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

N-methyl-N'-methyl-O-(m-PEG4)-O'-(propargyl-PEG4)-Cy3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562